Cefotaxime Eluting Niosomes as A Novel Approach to Potentiate the Antibacterial Activity

Multidrug resistance has resulted in hurtful infections on treatment with common antimicrobials and is associated health threatening problems. Antibiotic abuse care systems contributes to global resistance. β-lactams are the predominantly used antibiotics, most often cefotaxime, therefore facing a problem. Potent cephalosporin derivatives, β-lactamase inhibitors, prodrugs, drug nano-carriers approaches cutback bacterial An example of nanocarrier applied field antibacterial activity enhancement niosomes. Niosomes self-assembled vesicles made from non-ionic surfactants cholesterol also additives included or omitted that can provide good features such as antibiotic shielding, cleavage proofing, controlled release, specific targeting. Cefotaxime niosomes preparation done by Thin-Film Hydration method using Tween 40, span 60, stearylamine, cholesterol. The dried film was moisturised buffered solution cefotaxime at 45-55°C then final nanosized niosomal generated through probe sonication. A 27 formulas were prepared identified dynamic light scattering so polydispersity index vesicular size measured. selected formula (CN6) showed lowermost values prominent structure 106 nm diameter Transmission electron microscope compatibility Fourier Transform Infrared System analysis. CN6 remained unchanged Poly-dispersity after 100 days storage 2 to-80 C onsubsequent freeze drying reconstitution. Entrapment efficiency quantified ultracentrifugation discovered be 93 %. delivery cefotaxime-eluting been shown successful potentiation 160, 8, 640 40 times better than aqueous against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa respectively which obviously considerable drop minimum inhibitory concentrations versus this evaluated Agar well diffusion technique.